Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth

Molecules

Jie Kang²  Chao Liu²  Hongqing Wang²  Baoming Li²  Chao Li²  Ruoyun Chen¹ 

[1] State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;

关键词: (2R;    3R)-7-O-galloylplumbocatechin A;    Pithecellobium clypearia Benth;    neuraminidase (NA) of influenza virus;    anti-inflammatory activity;   

DOI  :  10.3390/molecules19044479

来源: mdpi

【 摘 要 】

One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) and three known flavonoids, (−)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (−)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecellobium clypearia Benth. Their structures were elucidated based on spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (HSQC and HMBC) experiments. In vitro assays, compounds 1 and 2 showed moderate inhibitory effects against influenza H1N1 virus neuraminidase (NA). Compounds 1–4 were all found to inhibit the expression of proinflammatory cytokines IL-6 or MCP-1 induced by influenza H1N1 virus in human A549 lung carcinoma cells.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.