Studies on the Bioactive Flavonoids Isolated from Pithecellobium clypearia Benth

Molecules

Chao Liu¹  Baoming Li¹  Ailin Liu¹  Chao Li¹  Ruoyun Chen¹  Jie Kang¹  Hongqing Wang¹ 

[1] State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China;

关键词: (2R,3R)-7-O-galloylplumbocatechin A;    Pithecellobium clypearia Benth;    neuraminidase (NA) of influenza virus;    anti-inflammatory activity;   

DOI  :  10.3390/molecules19044479

来源: DOAJ

【 摘 要 】

One new flavonoid named (2R,3R)-7-O-galloylplumbocatechin A (1) andthree known flavonoids, (−)-5,3',4',5'-tetrahydroxyflavan-7-gallate (2), (+)-3,5,3',4',5'-penta-hydroxyflavan-7-gallate (3), and (−)-7,4'-di-O-galloyltricetiflavan (4), were isolated from Pithecellobium clypearia Benth. Their structures were elucidated based on spectroscopic analysis, including homonuclear and heteronuclear correlation NMR (HSQC and HMBC) experiments. In vitro assays, compounds 1 and 2 showed moderate inhibitory effects against influenza H1N1 virus neuraminidase (NA). Compounds 1–4 were all found to inhibit the expression of proinflammatory cytokines IL-6 or MCP-1 induced by influenza H1N1 virus in human A549 lung carcinoma cells.

【 授权许可】

Unknown