Synthesis and Antitumor Activities of Phenanthrene-Based Alkaloids

Molecules

Songtao Li¹  Li Han¹  Liang Sun¹  Dan Zheng¹  Jiang Liu¹  Yingbo Fu¹  Xueshi Huang¹ 

[1] ¹Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China ²Laboratory of Cell Engineering and Cell Therapy, College of Basic Medical Science, China Medical University, Shenyang 110001, China ^†These authors contributed equally to this work.

关键词: PBTs;    synthesis;    cytotoxicity;   

DOI  :  10.3390/molecules14125042

来源: mdpi

【 摘 要 】

A series of phenanthrene-based tylophorine derivatives (PBTs) were synthesized and their cytotoxic activities against the H460 human large-cell lung carcinoma cell line were evaluated. Among these compounds, N-(3-hydroxy-2,6,7-tri-methoxyphenanthr-9-ylmethyl)-L-prolinol (5a), and N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-L-valinol (9) exhibited good activities, with IC₅₀ values of 11.6 and 6.1 mM, respectively.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.