Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases

Pharmaceuticals

Antoni Camins⁴  Felix Junyent⁴  Ester Verdaguer⁴  Carlos Beas-Zarate³  Argelia E. Rojas-Mayorquín²  Daniel Ortuño-Sahagún¹ 

[1] Laboratorio de Desarrollo y Regeneración Neural, Instituto de Neurobiología, Departamento de Biología Celular y Molecular, C.U.C.B.A, Universidad de Guadalajara, Guadalajara, Jalisco, México;UMR 975 INSERM, Thérapeutique Expérimentale de la neurodégénérescence, Centre de recherche de l'Institut du cerveau et de la moelle épiniére (CRICM), Université Pierre et Marie Curie, Hôpital de la Salpêtrière, 47 bld de l'Hôpital, 75651 Paris Cedex 13, Paris, France;Departamento de Biología Celular y Molecular, CUCBA, Universidad de Guadalajara, División de Neurociencias, Centro de Investigación Biomédica de Occidente, IMSS, Sierra Mojada 800, Col. Independencia, Guadalajara, Jalisco 44340, Mexico;Unitat de Farmacologia i Farmacognòsia i Institut de Biomedicina (IBUB), Centro de Investigación de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), Facultat de Farmàcia, Universitat de Barcelona, Nucli Universitari de Pedralbes, Av. Joan XXIII s/n 08028 Barcelona, Spain

关键词: resveratrol;    Alzheimer’s disease;    Parkinson’s disease;    SIRT1;   

DOI  :  10.3390/ph2030194

来源: mdpi

【 摘 要 】

The prevention of aging is one of the most fascinating areas in biomedicine. The first step in the development of effective drugs for aging prevention is a knowledge of the biochemical pathways responsible for the cellular aging process. In this context it seems clear that free radicals play a key role in the aging process. However, in recent years it has been demonstrated that the families of enzymes called sirtuins, specifically situin 1 (SIRT1), have an anti-aging action. Thus, the natural compound resveratrol is a natural compound that shows a very strong activation of SIRT1 and also shows antioxidant effects. By activating sirtuin 1, resveratrol modulates the activity of numerous proteins, including peroxisome proliferator-activated receptor coactivator-1α (PGC-1 alpha), the FOXO family, Akt (protein kinase B) and NFκβ. In the present review, we suggest that resveratrol may constitute a potential drug for prevention of ageing and for the treatment of several diseases due to its antioxidant properties and sirtuin activation.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.