Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade

International Journal of Molecular Sciences

Kenneth Maiese¹  Zhao Zhong Chong¹  Shaohui Wang¹ 

[1] Laboratory of Cellular and Molecular Signaling, Newark, NJ 07101, USA; E-Mails:

关键词: Akt;    Alzheimer’s disease;    apoptosis;    autophagy;    diabetes mellitus;    Huntington’s disease;    mammalian target of rapamycin (mTOR);    oxidative stress;    Parkinson’s disease;    phosphoinositide 3-kinase (PI 3-K);    SIRT1;   

DOI  :  10.3390/ijms131113830

来源: mdpi

【 摘 要 】

Oxidative stress impacts multiple systems of the body and can lead to some of the most devastating consequences in the nervous system especially during aging. Both acute and chronic neurodegenerative disorders such as diabetes mellitus, cerebral ischemia, trauma, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and tuberous sclerosis through programmed cell death pathways of apoptosis and autophagy can be the result of oxidant stress. Novel therapeutic avenues that focus upon the phosphoinositide 3-kinase (PI 3-K), Akt (protein kinase B), and the mammalian target of rapamycin (mTOR) cascade and related pathways offer exciting prospects to address the onset and potential reversal of neurodegenerative disorders. Effective clinical translation of these pathways into robust therapeutic strategies requires intimate knowledge of the complexity of these pathways and the ability of this cascade to influence biological outcome that can vary among disorders of the nervous system.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.