Palladium-Catalyzed Heck Coupling Reaction of Aryl Bromides in Aqueous Media Using Tetrahydropyrimidinium Salts as Carbene Ligands

Molecules

Sedat Yaşar¹  Emine Özge Özcan¹  Nevin Gürbüz¹  Bekir Çetinkaya¹ 

[1] ¹Department of Chemistry, Faculty of Science and Art, Gaziosmanpaşa University, 60240 Tokat, Turkey ²Department of Chemistry, Faculty of Science and Art, İnönü University, 44280 Malatya, Turkey ³Department of Chemistry, Faculty of Science, Ege University, 35100 İzmir, Turkey

关键词: carbene;    C-C coupling;    palladium/tetrahydropyrimidinium;    Heck coupling;   

DOI  :  10.3390/molecules15020649

来源: mdpi

【 摘 要 】

An efficient and stereoselective catalytic system for the Heck cross coupling reaction using novel 1,3-dialkyl-3,4,5,6-tetrahydropyrimidinium salts (1, LHX) and Pd(OAc)₂ loading has been reported. The palladium complexes derived from the salts 1a-f prepared in situ exhibit good catalytic activity in the Heck coupling reaction of aryl bromides under mild conditions.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.