FLUOROUS SUPPORTED SYNTHESIS OF PYRAZOLONE DERIVATIVES FROM ALLYLIC ALCOHOLS USING A PALLADIUM-CATALYZED STRATEGY

Química Nova

David, Michèle¹  Cupif, Jean-François¹  Université de Rennes1, Rennes, France¹  Amaral, Patrícia de Aguiar¹  Cariou, Alexandre¹  Gouault, Nicolas¹  Universidade do Extremo Sul Catarinense, Criciúma, Brazil¹ 

关键词:  pyrazolones;    fluorous tag;    Heck coupling;    allylic alcohols;   

DOI  :  10.5935/0100-4042.20160098

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Ten substituted pyrazolone derivatives were easily synthesized from perfluorinated allylic alcohols, via a straightforward two steps reaction involving a Heck-coupling/isomerization reaction and subsequent condensation of hydrazines. This fluorous supported methodology, that combines a cyclo-release approach and F-SPE purification allows for the obtaining of the final products with a good purity.

【 授权许可】

Unknown