Molecular Recognition Studies on Naphthyridine Derivatives

Molecules

José Carlos Iglesias-Sánchez¹  Dolores Santa María¹  Rosa M. Claramunt¹ 

[1] ¹Departamento de Química Orgánica y Bio-Orgánica, Facultad de Ciencias, UNED, Senda del Rey 9, E-28040 Madrid, Spain ²Instituto de Química Médica, CSIC, Juan de la Cierva 3, E-28006, Madrid, Spain

关键词: host-guest;    naphthyridine;    biotin;    acridine;    NMR titrations;   

DOI  :  10.3390/molecules15031213

来源: mdpi

【 摘 要 】

The association constants K_b of three hosts I–III designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1–5 are reported. ¹H-NMR titrations under two different concentration conditions have been employed to determine the association constants K_b. A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.