Fe3O4/eggshells composite as green catalyst for Hantzsch condensation in acridine synthesis

2nd International Conference on Current Progress in Functional Materials 2017

Cahyana, A.H.^1 ; Saepudin, E.^1 ; Surya, M.^1 ; Ardiansah, B.^1

Department of Chemistry, FMIPA, Universitas Indonesia, Kampus Depok, Jawa Barat

16424, Indonesia^1

关键词: acridine;    Acridine derivatives;    Biological properties;    Fe3O4/eggshell;    Hantzsch;    Heterogeneous catalyst;    Nitrogen heterocycles;    Pharmaceutical applications;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/496/1/012054/pdf
DOI  :  10.1088/1757-899X/496/1/012054

来源: IOP

【 摘 要 】

Acridine derivatives are a class of nitrogen heterocycles which have broad spectrum of important biological properties and pharmaceutical applications. Low-cost eggshells waste material was used as source of CaCO3 to modified magnetic Fe3O4 particles prepared from co-precipitation to serve as reusable heterogeneous catalyst. The synthesized eggshells based catalyst is characterized by X-ray diffraction (XRD) and TEM studies. The activity of the catalyst has been investigated in Hantzsch condensation reaction with good yields and simple work-up procedure. The synthesis of acridine derivative was achieved through a one-pot, three-component condensation of dimedone, aryl amine and aryl aldehydes utilizing Fe3O4/eggshells composite as catalyst under mild conditions. Maximum yield obtained is 91.3% with reflux condition, amount of catalyst 0.0254 g, and 1.5 h reaction time. Catalyst used can be separated magnetically and can be reused up to three times without significant decrease of yield. The synthesized compound was characterized using IR, UV-Vis and LC-MS.