Targets and Effects of Yessotoxin, Okadaic Acid and Palytoxin: A Differential Review

Marine Drugs

Antonella Franchini¹  Davide Malagoli¹ 

[1] Department of Biology, University of Modena and Reggio Emilia, 41125 Modena, Italy;

关键词: development;    FETAX;    marine toxins;    invertebrate;    vertebrate;    cell cultures;    toxin targets;   

DOI  :  10.3390/md8030658

来源: mdpi

【 摘 要 】

In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebrate and vertebrate cell cultures. OA and PTX, two toxins with a better established mode of action, are analyzed with regard to their effects on development. The amphibian Xenopus laevis is used as a model, and the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) as the experimental protocol.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland