Thermal Analysis Applied to Verapamil Hydrochloride Characterization in Pharmaceutical Formulations

Molecules

Maria Irene Yoshida¹  Elionai Cassiana Lima Gomes¹  Cristina Duarte Vianna Soares¹  Alexandre Frinhani Cunha¹ 

[1] ¹Departamento de Química, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627-31270-901 Belo Horizonte, MG, Brazil

关键词: verapamil hydrochloride;    thermal analysis;    degradation kinetics;    characterization;   

DOI  :  10.3390/molecules15042439

来源: mdpi

【 摘 要 】

Thermogravimetry (TG) and differential scanning calorimetry (DSC) are useful techniques that have been successfully applied in the pharmaceutical industry to reveal important information regarding the physicochemical properties of drug and excipient molecules such as polymorphism, stability, purity, formulation compatibility among others. Verapamil hydrochloride shows thermal stability up to 180 °C and melts at 146 °C, followed by total degradation. The drug is compatible with all the excipients evaluated. The drug showed degradation when subjected to oxidizing conditions, suggesting that the degradation product is 3,4-dimethoxybenzoic acid derived from alkyl side chain oxidation. Verapamil hydrochloride does not present the phenomenon of polymorphism under the conditions evaluated. Assessing the drug degradation kinetics, the drug had a shelf life (t₉₀) of 56.7 years and a pharmaceutical formulation showed t₉₀ of 6.8 years showing their high stability.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.