Synthesis of a Novel Biodegradable Polyurethane with Phosphatidylcholines

International Journal of Molecular Sciences

Jun Cao¹  Niancao Chen¹  Yuanwei Chen¹ 

[1] College of Polymer Science & Engineering, Sichuan University, Chengdu 610065, China; E-Mails:

关键词: polyurethanes;    phosphatidylcholine;    biodegradable;    blood compatibility;    polymer;    surface;   

DOI  :  10.3390/ijms11041870

来源: mdpi

【 摘 要 】

A novel polyurethane was successfully synthesized by chain-extension of biodegradable poly (l-lactide) functionalized phosphatidylcholine (PC) with hexamethylene diisocyanate (HDI) as chain extender (PUR-PC). The molecular weights, glass transition temperature (Tg) increased significantly after the chain-extension. The hydrophilicity of PUR-PC was better than the one without PC, according to a water absorption test. Moreover, the number of adhesive platelets and anamorphic platelets on PUR-PC film were both less than those on PUR film. These preliminary results suggest that this novel polyurethane might be a better scaffold than traditional biodegradable polyurethanes for tissue engineering due to its better blood compatibility. Besides, this study also provides a new method to prepare PC-modified biodegradable polyurethanes.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.