Recent Advances in Synthetic Bioelastomers

International Journal of Molecular Sciences

Rui Shi¹  Dafu Chen¹  Quanyong Liu³  Yan Wu³  Xiaochuan Xu²  Liqun Zhang³ 

[1] Laboratory of Bone Tissue Engineering of Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035, China; E-Mails:;Department of Spine Surgery of Beijing JiShuiTan Hospital, the Fourth Clinical Medical College of Peking University, Beijing 100035, China; E-Mails:;Beijing Key Laboratory on Preparation and Processing of Novel Polymer Materials at Beijing University of Chemical Technology, 100029, China; E-Mails:

关键词: bioelastomer;    biodegradable;    biocompatible;    polyurethanes;    polyphosphazenes;    poly(ether ester);    poly(ε-caprolactone);    poly(1;    3-trimethylene carbonate);    poly(polyol sebacate)s;    poly(diol-citrates);    poly(ester amide)s;   

DOI  :  10.3390/ijms10104223

来源: mdpi

【 摘 要 】

This article reviews the degradability of chemically synthesized bioelastomers, mainly designed for soft tissue repair. These bioelastomers involve biodegradable polyurethanes, polyphosphazenes, linear and crosslinked poly(ether/ester)s, poly(ε-caprolactone) copolymers, poly(1,3-trimethylene carbonate) and their copolymers, poly(polyol sebacate)s, poly(diol-citrates) and poly(ester amide)s. The in vitro and in vivo degradation mechanisms and impact factors influencing degradation behaviors are discussed. In addition, the molecular designs, synthesis methods, structure properties, mechanical properties, biocompatibility and potential applications of these bioelastomers were also presented.

【 授权许可】

CC BY   
© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.