Molecular Mechanism of Ochratoxin A Transport in the Kidney

Toxins

Naohiko Anzai¹  Promsuk Jutabha¹ 

[1] Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan;

关键词: ochratoxin A;    mycotoxin;    organic anion transporter;    kidney;    nephrotoxicity;   

DOI  :  10.3390/toxins2061381

来源: mdpi

【 摘 要 】

The mycotoxin, ochratoxin A (OTA), is thought to be responsible for Balkan endemic nephropathy. OTA accumulates in several tissues, especially in the kidneys and liver. The excretion of OTA into urine is thought to be mainly by tubular secretion, presumably via the organic anion transport system. Recently, several families of multispecific organic anion transporters have been identified: organic anion transporters (OATs), organic anion-transporting polypeptides (OATPs), oligopeptide transporters (PEPTs), and ATP-binding cassette (ABC) transporters, such as MRP2 and BCRP. These renal transporters mediate the transmembrane transport of OTA and play a pivotal role in the development of OTA-induced nephrotoxicity.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland