A Novel Human Organic Anion Transporter NPT4 Mediates the Transport of Ochratoxin A

Journal of Pharmacological Sciences

Promsuk Jutabha¹  Kohsuke Uchida²  Naohiko Anzai¹  Hitoshi Endou¹  Keitaro Hayashi²  Hiroyuki Sakurai¹  Mariko Domae² 

[1] Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Japan;Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Japan

关键词: ochratoxin A;    organic anion transporter;    nephrotoxicity;   

DOI  :  10.1254/jphs.10227SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(3)In the present study, we investigated the transport of nephrotoxic mycotoxin ochratoxin A (OTxA) by a novel human organic anion transporter hNPT4 using the Xenopus oocyte expression system. hNPT4 mediated time- and concentration-dependent uptake of OTxA (Km: 802.8 μM) in a pH- and voltage-sensitive manner. Cis-inhibition experiments suggest that the substrate selectivity of hNPT4 is similar to that of hOAT4. The fact that the Km of OTxA for the efflux transporter hNPT4 was much higher than those for the uptake transporters hOAT1 and hOAT3 may favor the accumulation of OTxA in the tubular cell and lead to nephrotoxicity.

【 授权许可】

Unknown