Microfluidic Systems for Biosensing

Sensors

Kuo-Kang Liu²  Ren-Guei Wu⁴  Yun-Ju Chuang¹  Hwa Seng Khoo⁴  Shih-Hao Huang³ 

[1] Department of Biomedical Engineering, Ming Chuang University, Taoyuan County 333, Taiwan; E-Mail:;School of Engineering, University of Warwick, Coventry CV4 7AL, UK;Department of Mechanical and Mechatronic Engineering, National Taiwan Ocean University, Keelung 202-24, Taiwan; E-Mail:;Department of Engineering and System Science, National Tsing-Hua University, Hsinchu, Taiwan; E-Mails:

关键词: lab-on-a-chip;    Micro total analysis systems (μTAS);    droplet-based;    microfluidic;    MEMS;    tissue engineering;    stem cell;    drug delivery;   

DOI  :  10.3390/s100706623

来源: mdpi

【 摘 要 】

In the past two decades, Micro Fluidic Systems (MFS) have emerged as a powerful tool for biosensing, particularly in enriching and purifying molecules and cells in biological samples. Compared with conventional sensing techniques, distinctive advantages of using MFS for biomedicine include ultra-high sensitivity, higher throughput, in-situ monitoring and lower cost. This review aims to summarize the recent advancements in two major types of micro fluidic systems, continuous and discrete MFS, as well as their biomedical applications. The state-of-the-art of active and passive mechanisms of fluid manipulation for mixing, separation, purification and concentration will also be elaborated. Future trends of using MFS in detection at molecular or cellular level, especially in stem cell therapy, tissue engineering and regenerative medicine, are also prospected.

【 授权许可】

CC BY   
© 2010 by the authors licensee MDPI, Basel, Switzerland.