The Systemic and Pulmonary Immune Response to Staphylococcal Enterotoxins

Toxins

Sanjeev Kumar¹  Antoine Ménoret¹  Soo-Mun Ngoi¹ 

[1] Department of Immunology-MC3710, University of Connecticut Heath Center, 263 Farmington Avenue, Farmington, CT 06030, USA;

关键词: superantigen;    T cells;    staphylococcal enterotoxins;   

DOI  :  10.3390/toxins2071898

来源: mdpi

【 摘 要 】

In response to environmental cues the human pathogen Staphylococcus aureus synthesizes and releases proteinaceous enterotoxins. These enterotoxins are natural etiologic entities of severe food poisoning, toxic shock syndrome, and acute diseases. Staphylococcal enterotoxins are currently listed as Category B Bioterrorism Agents by the Center for Disease Control and Prevention. They are associated with respiratory illnesses, and may contribute to exacerbation of pulmonary disease. This likely stems from the ability of Staphylococcal enterotoxins to elicit powerful episodes of T cell stimulation resulting in release of pro-inflammatory cytokines. Here, we discuss the role of the immune system and potential mechanisms of disease initiation and progression.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland