Peppermint Oil Decreases the Production of Virulence-Associated Exoproteins by Staphylococcus aureus

Molecules

Jing Li¹  Jing Dong¹  Jia-Zhang Qiu¹  Jian-Feng Wang¹  Ming-Jing Luo¹  Hong-En Li¹  Bing-Feng Leng¹  Wen-Zhi Ren¹ 

[1] Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China ^†These authors contributed equally to this work.

关键词: Staphylococcus aureus;    peppermint oil;    α-toxin;    staphylococcal enterotoxins;    toxic shock syndrome toxin 1;   

DOI  :  10.3390/molecules16021642

来源: mdpi

【 摘 要 】

The present study aimed to evaluate the antimicrobial activity of peppermint oil against Staphylococcus aureus, and further investigate the influence of peppermint oil on S. aureus virulence-related exoprotein production. The data show that peppermint oil, which contained high contents of menthone, isomenthone, neomenthol, menthol, and menthyl acetate, was active against S. aureus with minimal inhibitory concentrations (MICs) ranging from 64-256 µg/mL, and the production of S. aureus exotoxins was decreased by subinhibitory concentrations of peppermint oil in a dose-dependent manner. The findings suggest that peppermint oil may potentially be used to aid in the treatment of S. aureus infections.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.