Modular Synthesis of Polyphenolic Benzofurans, and Application in the Total Synthesis of Malibatol A and Shoreaphenol

Molecules

David Y.-K. Chen¹  Qiang Kang¹ 

[1] Chemical Synthesis Laboratory at Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, No. 03-08, 138667, Singapore

关键词: cascade reaction;    polyphenol;    resveratrol;    Friedel-Crafts;    natural product;    total synthesis;   

DOI  :  10.3390/molecules15095909

来源: mdpi

【 摘 要 】

A modular strategy for the synthesis of hexacyclic dimeric resveratrol polyphenolic benzofurans is reported. The developed synthetic technology was applied to the total synthesis of malibatol A, shoreaphenol, and other biologically relevant poly-phenols.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.