Flavonoids: Antioxidants Against Atherosclerosis

Nutrients

Davide Grassi¹  Giovambattista Desideri¹ 

[1] Department of Internal Medicine and Public Health, University of L’Aquila, L’Aquila, 67100 Italy;

关键词: oxidative stress;    endothelial dysfunction;    atherosclerosis;    antioxidants;    flavonoids;   

DOI  :  10.3390/nu2080889

来源: mdpi

【 摘 要 】

Oxidative stress results from an imbalance between excessive formation of reactive oxygen species (ROS) and/or reactive nitrogen species and limited antioxidant defences. Endothelium and nitric oxide (NO) are key regulators of vascular health. NO bioavailability is modulated by ROS that degrade NO, uncouple NO synthase, and inhibit synthesis. Cardiovascular risk conditions contribute to oxidative stress, causing an imbalance between NO and ROS, with a relative decrease in NO bioavailability. Dietary flavonoids represent a range of polyphenolic compounds naturally occurring in plant foods. Flavonoids are potentially involved in cardiovascular prevention mainly by decreasing oxidative stress and increasing NO bioavailability.

【 授权许可】

CC BY   
© 2010 by the authors; licensee MDPI, Basel, Switzerland.