Lobophytones O–T, New Biscembranoids and Cembranoid from Soft Coral Lobophytum pauciflorum

Marine Drugs

Pengcheng Yan²  Zhiwei Deng¹  Leen van Ofwegen³  Peter Proksch⁴ 

[1] Analytical and Testing Center, Beijing Normal University, Beijing, 100875, China; E-Mail:;State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China; E-Mail:;Netherlands Centre for Biodiversity Naturalis, 2300 RA Leiden, The Netherlands; E-Mail:;Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany; E-Mail:

关键词: soft coral;    Lobophytum pauciflorum;    lobophytones O-T;    structure elucidation;    NO inhibition;    antibiotic activity;   

DOI  :  10.3390/md8112848

来源: mdpi

【 摘 要 】

Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of five new biscembranoids named lobophytones O–S (1–5) and a new “monomeric” cembrane lobophytone T (6). The structures of the new compounds were elucidated by interpretation of 1D and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic data in association with MS and IR data. Lobophytone Q showed significant inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophages, while lobophytones Q and T showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.

【 授权许可】

CC BY   
© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland