Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives

Molecules

Yahia Nasser Mabkhot¹  Nabila Abd Elshafy Kheder¹ 

[1] ¹Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia ²Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt ^†Current Address: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, Abha, Saudi Arabia

关键词: thieno[2;    3-b]thiophene;    bis-heterocycles;    nucleophilic addition;    2-bromo-1-phenylethanone;   

DOI  :  10.3390/molecules15129418

来源: mdpi

【 摘 要 】

A facile and convenient synthesis of bis(2-(1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile), bis((3-amino-5-(methylthio)-1H-pyrazol-4-yl)methanone) and bis(2-thioxo-1,2-dihydropyrimidine-5-carbonitrile) derivatives incorporating a thieno- [2,3-b]thiophene moiety via versatile, readily accessible diethyl 3,4-dimethylthieno-[2,3-b]thiophene-2,5-dicarboxylate (1) is described.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.