Synthesis and Antimicrobial Activity of Some New Thieno[2,3-b]thiophene Derivatives

Molecules

Yahia Nasser Mabkhot¹  Nabila Abdelshafy Kheder² 

[1] Department of Chemistry, Faculty of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt

关键词: thieno[2;    3-b]thiophene;    nucleophilic addition;    hydrazonoyl halides;    bis-pyrazole;    antimicrobial activity;   

DOI  :  10.3390/molecules18044669

来源: mdpi

【 摘 要 】

A series of thieno[2,3-b]thiophene moiety-containing bis-cyanopyrazoles 5a–c, bis-aminopyrazole 9 and bis-pyridazine derivatives 11 were synthesized and evaluated in vitro for their antimicrobial potential. The antimicrobial activity of some selected products was evaluated and showed good results. 5,5'-(3,4-Dimethylthieno[2,3-b]thiophene-2,5-diyl)bis(3-acetyl-1-(4-chlorophenyl)-1H-pyrazole-4-carbonitrile) (5d) was found to be more potent than the standard drug amphotericin B against Geotricum candidum and equipotent to amphotericin BagainstSyncephalastrum racemosum. In addition, it was found to be equipotent to the standard drug Penicillin G againstStaphylococcus aureus.Moreover, it was more potent than the standard drug streptomycinagainst Pseudomonas aeruginosa and Escherichia coli.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.