Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections

Molecules

Victor Alves Carneiro¹  Hélcio Silva dos Santos¹  Francisco Vassiliepe Sousa Arruda¹  Paulo Nogueira Bandeira¹  Maria Rose Jane Ribeiro Albuquerque¹  Maria Olívia Pereira¹  Mariana Henriques¹  Benildo Sousa Cavada¹ 

[1] ¹Department of Biochemistry and Molecular Biology, Faculty of Medicine of Sobral, Federal University of Ceará, Fortaleza, CE, Brazil

关键词: casbane diterpene;    biofilm-associated infections control;    natural antimicrobials;    bacteria and yeast;   

DOI  :  10.3390/molecules16010190

来源: mdpi

【 摘 要 】

Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.