Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway

Molecules

Jian-Ye Zhang¹  Yong-Ju Liang¹  Hu-Biao Chen¹  Li-Sheng Zheng¹  Yan-Jun Mi¹  Fang Wang¹  Xiao-Qin Zhao¹  Xiao-Kun Wang¹  Hui Zhang¹ 

[1] ¹Department of Pharmaceutical Sciences, School of Basic Science, Guangzhou Medical College, Guangzhou 510182, China

关键词: euphorbia factor L3;    caper euphorbia seed;    apoptosis;    mitochondrial pathway;   

DOI  :  10.3390/molecules16043222

来源: mdpi

【 摘 要 】

In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC₅₀ values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.