Molecules | |
Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway | |
Jian-Ye Zhang1  Yong-Ju Liang1  Hu-Biao Chen1  Li-Sheng Zheng1  Yan-Jun Mi1  Fang Wang1  Xiao-Qin Zhao1  Xiao-Kun Wang1  Hui Zhang1  | |
[1] 1Department of Pharmaceutical Sciences, School of Basic Science, Guangzhou Medical College, Guangzhou 510182, China | |
关键词: euphorbia factor L3; caper euphorbia seed; apoptosis; mitochondrial pathway; | |
DOI : 10.3390/molecules16043222 | |
来源: mdpi | |
【 摘 要 】
In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
【 预 览 】
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