International Journal of Molecular Sciences | |
Mechanisms Underlying Apoptosis-Inducing Effects of Kaempferol in HT-29 Human Colon Cancer Cells | |
Hyun Sook Lee5  Han Jin Cho2  Rina Yu3  Ki Won Lee4  Hyang Sook Chun1  | |
[1] Food Science and Technology, Chung-Ang University, An-Sung 456-756, Korea; E-Mail:;Department of Food and Nutrition, Hallym University, Chuncheon 200-702, Korea; E-Mails:;Department of Food Science and Nutrition, University of Ulsan, Ulsan 680-749, Korea; E-Mail:;Advanced Institutes of Convergence Technology, Seoul National University, Suwon, Gyonggi-do 443-270, Korea; E-Mail:;Department of Food Science and Nutrition, Dongseo University, 47 Jurye-ro, Sasang-gu, Busan 617-716, Korea; E-Mail: | |
关键词: kaempferol; colon cancer; apoptosis; mitochondrial pathway; cell-death receptor pathway; | |
DOI : 10.3390/ijms15022722 | |
来源: mdpi | |
【 摘 要 】
We previously noted that kaempferol, a flavonol present in vegetables and fruits, reduced cell cycle progression of HT-29 cells. To examine whether kaempferol induces apoptosis of HT-29 cells and to explore the underlying molecular mechanisms, cells were treated with various concentrations (0–60 μmol/L) of kaempferol and analyzed by Hoechst staining, Annexin V staining, JC-1 labeling of the mitochondria, immunoprecipitation,
【 授权许可】
CC BY
© 2014 by the authors; licensee MDPI, Basel, Switzerland
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