Allelic Imbalances in Radiation—Associated Acute Myeloid Leukemia

Genes

Sergiy V. Klymenko¹  Jan Smida²  Michael J. Atkinson²  Volodymir G. Bebeshko¹  Michaela Nathrath³ 

[1] Institute of Clinical Radiology, Research Centre for Radiation Medicine, 53 Melnikova, 04050 Kyiv, Ukraine; E-Mails:;Institute of Pathology, Helmholtz Zentrum Muenchen–German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany;E-Mail:;Institute of Radiobiology, Helmholtz Zentrum Muenchen–German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany;E-Mail:

关键词: acute myeloid leukemia;    ionizing radiation;    Chernobyl accident;    single nucleotide polymorphism;    microarray;   

DOI  :  10.3390/genes2020384

来源: mdpi

【 摘 要 】

Acute myeloid leukemia (AML) can develop as a secondary malignancy following radiotherapy, but also following low-dose environmental or occupational radiation exposure. Therapy-related AML frequently carries deletions of chromosome 5q and/or 7, but for low-dose exposure associated AML this has not been described. For the present study we performed genome-wide screens for loss-of-heterozygosity (LOH) in a set of 19 AML cases that developed after radiation-exposure following the Chernobyl accident. Using Affymetrix SNP arrays we found large regions of LOH in 16 of the cases. Eight cases (42%) demonstrated LOH at 5q and/or 7, which is a known marker of complex karyotypic changes and poor prognosis. We could show here for the first time that exposure to low-dose ionizing radiation induces AML with molecular alterations similar to those seen in therapy-related cases.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.