Prolinethioamides versus Prolinamides in Organocatalyzed Aldol Reactions—A Comparative Study

Symmetry

Dorota Gryko¹  Mikołaj Chromiński¹ 

[1] Institute of Organic Chemistry PAS, Kasprzaka 44/52, 01-224 Warsaw, Poland

关键词: organocatalysis;    prolinethioamides;    prolinamides;    aldol reaction;    enamine-iminium catalysis;   

DOI  :  10.3390/sym3020265

来源: mdpi

【 摘 要 】

Various organocatalysts have been developed for the aldol reaction but particular attention has been paid to prolinamide derivatives. They are easy to prepare and their catalytic activity can be readily tuned through structural modification. In this review, the comparison of catalytic activities between prolinethioamides and their respective amides in direct asymmetric aldol reactions is presented.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.