Nobel Prize in Chemistry 2021: Asymmetric Organocatalysis – An Ingenious Tool for Building Molecules

Resonance

article

Ramesh Ramapanicker¹  Vinod K Singh¹ 

[1] Department of Chemistry Indian Institute of Technology Kanpur Kanpur

关键词: Asymmetric synthesis;    organocatalysis;    enamines;    iminium ions;    aldol reaction;    Diels–Alder reaction;    proline;    imidazolidinone.;   

DOI  :  10.1007/s12045-022-1512-1

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

The Nobel Prize in Chemistry for the year 2021 was awardedto Prof. Benjamin List of Max-Planck-Institut fur Kohlenforschung,M¨ulheim an der Ruhr, Germany and Prof. DavidW.C. MacMillan of Princeton University, Princeton, NJ, USA.The award was given for their contribution to developing andpopularizing asymmetric organocatalysis as an efficient toolfor the construction of organic molecules. Organocatalysisis the use of small organic molecules to catalyze organic reactions,which has gained attention for bringing about asymmetrictransformations without the use of metal catalysts. BothProf. List and Prof. MacMillan pioneered the activation ofcarbonyl compounds by converting them to iminium ions orenamines using optically active secondary amines as organocatalysts.This article will discuss the contributions of List andMacMillan with brief introductions to the problems they attemptedto solve using organocatalysis.

【 授权许可】

Others