Chiral phanephos derived catalysts and their application in asymmetric catalysis

Enantioselective catalysis;Asymmetric synthesis;Organophosphorus compounds--Derivatives

Konrad, Tina Maria ; Clarke, Matt ; Clarke, Matt

University:University of St Andrews

Department:Chemistry (School of)

关键词: Enantioselective catalysis;    Asymmetric synthesis;    Organophosphorus compounds--Derivatives;   

Others  :  https://research-repository.st-andrews.ac.uk/bitstream/handle/10023/4499/TinaKonradPhDThesis.pdf?sequence=3&isAllowed=y

来源: DR-NTU

【 摘 要 】

The research presented in this thesis is a project funded by the EU-network of theMarie Curie project NANO-HOST in collaboration with partner institutes. The aims of thisnetwork are to develop innovative methods for the preparation, recovery and reuse ofsingle-site, nanostructured catalytic materials, and further on apply them in combinationwith specifically engineered reactors for a sustainable production process for makinghigh value fine chemicals.One part of this project was to prepare chiral diphosphine ligands and theircomplexes for currently challenging reactions, such as asymmetric carbonylations(homogeneous catalysis). Catalytic studies of these chiral diphosphine ligands werecarried out in asymmetric hydroxy-and alkoxy-carbonylations and hydrogenationreactions. The second part of this project was the heterogenisation of these chiralhomogeneous complexes through collaborations with the network partners andfurthermore their catalytic behavior was studied.