Microfluidic Technologies for Synthetic Biology

International Journal of Molecular Sciences

Parisutham Vinuselvi²  Seongyong Park¹  Minseok Kim¹  Jung Min Park²  Taesung Kim¹ 

[1] School of Mechanical and Advanced Materials Engineering, Ulsan National Institute of Science and Technology, 100 Banyeon-ri, Ulsan 689–798, Korea; E-Mails:;School of Nano-Bioscience and Chemical Engineering, Ulsan National Institute of Science and Technology, 100 Banyeon-ri, Ulsan 689–798, Korea; E-Mails:

关键词: microfluidics;    synthetic biology;    genetic circuits;    gene expression and regulation;    metabolite detection;    whole-cell analysis;   

DOI  :  10.3390/ijms12063576

来源: mdpi

【 摘 要 】

Microfluidic technologies have shown powerful abilities for reducing cost, time, and labor, and at the same time, for increasing accuracy, throughput, and performance in the analysis of biological and biochemical samples compared with the conventional, macroscale instruments. Synthetic biology is an emerging field of biology and has drawn much attraction due to its potential to create novel, functional biological parts and systems for special purposes. Since it is believed that the development of synthetic biology can be accelerated through the use of microfluidic technology, in this review work we focus our discussion on the latest microfluidic technologies that can provide unprecedented means in synthetic biology for dynamic profiling of gene expression/regulation with high resolution, highly sensitive on-chip and off-chip detection of metabolites, and whole-cell analysis.

【 授权许可】

CC BY   
© 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.