Pharmaceutics | |
Fliposomes: pH-Sensitive Liposomes Containing a |
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Nataliya M. Samoshina2  Xin Liu1  Barbora Brazdova1  Andreas H. Franz1  Vyacheslav V. Samoshin1  | |
[1] Department of Chemistry, University of the Pacific, 3601 Pacific Ave., Stockton, CA 95211, USA;Department of Pharmaceutics and Medicinal Chemistry, University of the Pacific, 751 Brookside Road, Stockton, CA 95211, USA | |
关键词: pH-sensitive liposomes; fliposomes; polyethyleneglycol (PEG); conformational switch; controlled drug release; triggered release; | |
DOI : 10.3390/pharmaceutics3030379 | |
来源: mdpi | |
【 摘 要 】
Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic conformational flip upon protonation that disrupts the liposome membrane and causes rapid release of cargo specifically in areas of increased acidity. pH-sensitive liposomes containing the amphiphile (
【 授权许可】
CC BY
© 2011 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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