Lobocrassins A–E: New Cembrane-Type Diterpenoids from the Soft Coral Lobophytum crassum

Marine Drugs

Chia-Ying Kao⁷  Jui-Hsin Su⁷  Mei-Chin Lu⁷  Tsong-Long Hwang⁴  Wei-Hsien Wang⁶  Jih-Jung Chen²  Jyh-Horng Sheu³  Yueh-Hsiung Kuo¹  Ching-Feng Weng⁵  Lee-Shing Fang⁸  Zhi-Hong Wen³ 

[1] Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan; E-Mail:;Department of Pharmacy, Tajen University, Pingtung 907, Taiwan; E-Mail:;Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mails:;Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan; E-Mail:;Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan; E-Mail:;National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; E-Mail:;Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan; E-Mails:;Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan; E-Mail:

关键词: lobocrassin;    cembrane;    Lobophytum crassum;    cytotoxicity;    superoxide anion;    elastase;   

DOI  :  10.3390/md9081319

来源: mdpi

【 摘 要 】

Five new cembrane-type diterpenoids, lobocrassins A–E (1–5), were isolated from the soft coral Lobophytum crassum. The structures of cembranes 1–5 were established by spectroscopic and chemical methods and by comparison of the spectral data with those of known cembrane analogues. Lobocrassin A (1) is the first cembranoid possessing an α-chloromethyl-α-hydroxy-γ-lactone functionality and is the first chlorinated cembranoid from soft corals belonging to the genus Lobophytum. Lobocrassins B (2) and C (3) were found to be the stereoisomers of the known cembranes, 14-deoxycrassin (6) and pseudoplexaurol (7), respectively. Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.