Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

Marine Drugs

Cheng-Hung Lee¹  Chia-Ying Kao²  Shih-Yao Kao²  Chih-Han Chang¹  Jui-Hsin Su²  Tsong-Long Hwang⁴  Yueh-Hsiung Kuo⁵  Zhi-Hong Wen³ 

[1] Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan;Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan;;Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, TaiwanGraduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan;School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources and Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan;

关键词: menelloide;    germacrane;    Menella;    lobocrassin;    cembrane;    Lobophytum;    elastase;   

DOI  :  10.3390/md10020427

来源: mdpi

【 摘 要 】

A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils.

【 授权许可】

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.