Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum

Marine Drugs

Shih-Tseng Lin²  Shang-Kwei Wang¹ 

[1] Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan;

关键词: soft coral;    Lobophytum crassum;    cytotoxicity;   

DOI  :  10.3390/md9122705

来源: mdpi

【 摘 要 】

Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (1–3) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 1–4 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED₅₀ of 3.6 μg/mL.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.