Potential Antibacterial Activity of Carvacrol-Loaded Poly(DL-lactide-co-glycolide) (PLGA) Nanoparticles against Microbial Biofilm

International Journal of Molecular Sciences

Antonio Iannitelli¹  Rossella Grande¹  Antonio Di Stefano¹  Mara Di Giulio¹  Piera Sozio¹  Lucinda Janete Bessa¹  Sara Laserra¹  Cecilia Paolini²  Feliciano Protasi² 

[1] Department of Drug Sciences, Faculty of Pharmacy; University G. d’Annunzio, Via dei Vestini 31, Chieti 66100, Italy; E-Mails:;CeSI-Center for Research on Ageing & DNI-Department of Neuroscience and Imaging, University G. d’Annunzio, Chieti-Pescara, Via dei Vestini 31, Chieti 66100, Italy; E-Mails:

关键词: carvacrol;    biofilm;    PLGA nanoparticles;   

DOI  :  10.3390/ijms12085039

来源: mdpi

【 摘 要 】

The ability to form biofilms contributes significantly to the pathogenesis of many microbial infections, including a variety of ocular diseases often associated with the biofilm formation on foreign materials. Carvacrol (Car.) is an important component of essential oils and recently has attracted much attention pursuant to its ability to promote microbial biofilm disruption. In the present study Car. has been encapsulated in poly(dl-lactide-co-glycolide (PLGA) nanocapsules in order to obtain a suitable drug delivery system that could represent a starting point for developing new therapeutic strategies against biofilm-associated infections, such as improving the drug effect by associating an antimicrobial agent with a biofilm viscoelasticity modifier.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.