Kinase Inhibitors from Marine Sponges

Marine Drugs

Danielle Skropeta¹  Natalie Pastro¹ 

[1] School of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia; E-Mails:

关键词: marine sponges;    marine natural products;    protein kinase inhibitors;    cell regulation;    anticancer agents;   

DOI  :  10.3390/md9102131

来源: mdpi

【 摘 要 】

Protein kinases play a critical role in cell regulation and their deregulation is a contributing factor in an increasing list of diseases including cancer. Marine sponges have yielded over 70 novel compounds to date that exhibit significant inhibitory activity towards a range of protein kinases. These compounds, which belong to diverse structural classes, are reviewed herein, and ordered based upon the kinase that they inhibit. Relevant synthetic studies on the marine natural product kinase inhibitors have also been included.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland