Nepheliosyne B, a New Polyacetylenic Acid from the New Caledonian Marine Sponge Niphates sp.

Marine Drugs

Nathalie Legrave³  Souhir Hamrouni-Buonomo³  Maeva Dufies¹  Vincent Guérineau⁴  Jean Vacelet²  Patrick Auberger¹  Philippe Amade³ 

[1] Mediterranean Centre of Molecular Medicine (C3M), INSERM UMR 1065, Team 2: Cell Death Differentiation and Cancer, Batiment ARCHIMED, 151 Route de Saint-Antoine de Ginestière, BP2 3194, 06204 Nice Cedex 3, France; E-Mails:;Aix-Marseille University, CNRS UMR 7263, Mediterranean Institute of Biodiversity and Marine and Continental Ecology (IMBE), Station Marine d’Endoume, Rue de la Batterie des Lions, Marseille 13007, France; E-Mail:;Chemistry Institute of Nice (ICN), UMR 7272 CNRS, Bioactive Molecules, University of Nice-Sophia Antipolis, ParcValrose, F-06108 Nice Cedex 02, France; E-Mails:;Gif Research Centre, Chemistry Institute of Natural Substances, CNRS Avenue de la Terrasse, 91198 Gif-Sur-Yvette Cedex, France; E-Mail:

关键词: marine natural products;    highly oxygenated polyacetylenes;    marine sponges;    Porifera;    Haplosclerida;   

DOI  :  10.3390/md11072282

来源: mdpi

【 摘 要 】

A new C₄₇ polyoxygenated acetylenic acid, nepheliosyne B (2), along with the previously described nepheliosyne A (1), have been isolated from the New Caledonian marine sponge Niphates sp. Their structures have been elucidated on the basis of extensive spectroscopic analyses. These metabolites exhibited a moderate cytotoxicity against K562, U266, SKM1, and Kasumi cancer cell lines.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.