Related Factors of Insulin Resistance in Korean Children: Adiposity and Maternal Insulin Resistance

International Journal of Environmental Research and Public Health

Young-Gyu Cho¹  Jae-Heon Kang¹  Yang-Im Hur¹  Jihyun Song² 

[1] Department of Family Medicine, Seoul-Paik Hospital, College of Medicine, Inje University, 85 Jeo-dong 2-ga, Jung-gu, Seoul 100032, Korea;Division of Metabolic Diseases, Center for Biomedical Sciences, National Institute of Health, 187 Osongsaengmyeong 2-ro, Gangoe-myeon, Cheongwon-gun, Chungcheongbuk-do 363951, Korea;

关键词: insulin resistance;    child;    parent;    adiposity;    lifestyle habit;   

DOI  :  10.3390/ijerph8124596

来源: mdpi

【 摘 要 】

Increased adiposity and unhealthy lifestyle augment the risk for type 2 diabetes in children with familial predisposition. Insulin resistance (IR) is an excellent clinical marker for identifying children at high risk for type 2 diabetes. This study was conducted to investigate parental, physiological, behavioral and socio-economic factors related to IR in Korean children. This study is a cross-sectional study using data from 111 children aged 7 years and their parents. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated using fasting glucose and insulin level as a marker of IR. All children’s adiposity indices (r = 0.309–0.318, all P-value = 0.001) and maternal levels of fasting insulin (r = 0.285, P-value = 0.003) and HOMA-IR (r = 0.290, P-value = 0.002) were positively correlated with children’s HOMA-IR level. There was no statistical difference of children’s HOMA-IR level according to children’s lifestyle habits and socioeconomic status of families. An increase of 1 percentage point in body fat was related to 2.7% increase in children’s HOMA-IR (P-value < 0.001) and an increase of 1% of maternal level of HOMA-IR was related to 0.2% increase in children’s HOMA-IR (P-value = 0.002). This study shows that children’s adiposity and maternal IR are positively associated with children’s IR.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.