Comparison between cafeteria and high-fat diets in the induction of metabolic dysfunction in mice

International Journal of Physiology, Pathophysiology and Pharmacology

Miriam H Fonseca-Alaniz¹  Fabiana Sant´Anna Evangelista¹  Talita S Higa¹  Acauã V Spinola¹ 

关键词: Diet;    adiposity;    insulin resistance;    leptin;    lipid profile;    mice;   

DOI  :  

学科分类：生理学与病理学

来源: e-Century Publishing Corporation

【 摘 要 】

This study sought to compare the metabolic responses induced by high-fat (HF) diet and cafeteria (CA) diet in mice. Adult male C57BL/6J mice were assigned into groups fed a chow (C, n=13), CA (n=12) or HF (n=11) diet during 12 weeks. Diets did not change body weight, Lee index, inguinal subcutaneous fat, the weight of organs and muscles, resting arterial pressure and heart rate. CA and HF increased visceral fat pad mass compared to C group, but only CA group showed greater adipocyte diameter and food intake compared to the C. Food intake was reduced in HF compared to C group. CA and HF showed hyperglycemia in the 3^rd, 6^th, 9^th and 12^th week and all values were higher in CA than HF, except in the 6^th week. CA group showed glucose intolerance (GI) in the 6^th week, while HF group did not show GI until the 9^th week. CA decreased insulin sensitivity compared to C in the 12^th week (kITT=3.3±0.2%/min vs. 4.2±0.1%/min). CA and HF groups presented higher insulin, leptin, total cholesterol, LDL-C, triglycerides and FFA levels compared to the C group. Total cholesterol and LDL-C in mg/dL were higher in the HF (161.9±7.2 and 57.5±13.4) than the CA (110.5±9.1 and 48.5±11.4), and HDL-C was higher in the HF than in the C and CA groups. In conclusion, the CA diet was more efficient to induce hyperphagia, adipocyte hypertrophy, hyperglycemia, earlier GI and insulin resistance, while the HF diet was more efficient to induce lipid profile changes.

【 授权许可】

Unknown