Role of inflammation and oxidative stress in post‐menopausal oestrogen‐dependent breast cancer

Journal of Cellular and Molecular Medicine

Clelia Madeddu⁵  Giulia Gramignano¹  Carlo Floris³  Giuseppe Murenu⁴  Giuseppe Sollai² 

[1] Medical Oncology Unit, San Gavino Hospital, San Gavino, Italy;Department of Oncological Surgery, “A. Businco” Oncological Hospital, Cagliari, Italy;Department of Medical Oncology, Nuova Casa di Cura, Cagliari, Italy;Department of Experimental Surgery, “A. Businco” Oncological Hospital, Cagliari, Italy;Department of Medical Sciences “Mario Aresu”, University of Cagliari, Cagliari, Italy

关键词: oestrogen‐dependent breast cancer;    leptin;    adiposity;    Interleukin‐6;    oxidative stress;   

DOI  :  10.1111/jcmm.12413

来源: Wiley

【 摘 要 】

Abstract

Weight gain and obesity are among the most important risk factors for post-menopausal oestrogen-dependent breast cancer (EDBC). Weight gain is associated with oxidative stress, which in turn promotes breast cancer progression. We carried out a prospective study in 216 consecutive post-menopausal breast cancer patients aiming to examine the correlations between traditional prognostic factors (tumour size, T, nodal, N, grading, G, and metastasis status, M), and body mass index (BMI), leptin, pro-inflammatory cytokines (Interleukin, IL,-6 and tumour necrosis factor-alpha, TNF-α), and oxidative stress (reactive oxygen species, ROS, glutathione peroxidase, GPx, superoxide dismutase, SOD) among patients with oestrogen receptor (ER)+ and ER− breast cancers. Distribution of T, N and M categories did not differ between ER+ and ER− breast cancer patients. ER− patients showed a higher incidence of G3 tumours. Weight, BMI, leptin, IL-6 and ROS were higher in ER+ compared with ER− patients. Among ER+ patients, BMI, leptin, IL-6 and ROS correlated with T and M. Leptin, IL-6 and ROS were positively correlated also with N. Among ER− patients, BMI and leptin did not correlate with any of prognostic parameters, whereas a positive correlation between IL-6, ROS and M was found. Multivariate regression analysis showed that BMI, leptin, IL-6 and ROS were predictive for T, N and M in ER+ patients. Weight gain, inflammation and oxidative stress are involved in EDBC prognosis. Their modulation through antidiabetic, anti-inflammatory and antioxidants drugs combined with endocrine therapy may constitute a targeted approach in post-menopausal EDBC.

【 授权许可】

CC BY   
© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

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