Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation

International Journal of Molecular Sciences

Nagisa Arimitsu¹  Jun Shimizu¹  Naruyoshi Fujiwara¹  Kenji Takai¹  Erika Takada¹  Takao Kono²  Yuji Ueda¹  Tomoko Suzuki¹ 

[1] Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan; E-Mails:;Department of Neurosurgery, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan; E-Mail:

关键词: neural stem/progenitor cells;    chemokines;    cell migration;    chemokine receptor;   

DOI  :  10.3390/ijms13032636

来源: mdpi

【 摘 要 】

Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to understand the molecular mechanisms governing neural regeneration of the damaged motor cortex after the transplantation. Recent investigations disclosed that chemokines participated in the regulation of migration and maturation of neural cell grafts. In this review, we summarize the involvement of inflammatory chemokines including stromal cell derived factor 1 (SDF1) in neural regeneration after ES cell derived neural stem/progenitor cell transplantation in mouse stroke models.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.