Antiviral Activities and Putative Identification of Compounds in Microbial Extracts from the Hawaiian Coastal Waters

Marine Drugs

Jing Tong¹  Hank Trapido-Rosenthal³  Jun Wang⁴  Youwei Wang²  Qing X. Li⁴ 

[1] Department of Public Health Sciences, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA;Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Institute of Traditional Chinese Medicine & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China;Center for Marine Microbial Ecology and Diversity, University of Hawaii at Manoa, Honolulu, HI 96822, USA;Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, East-West Road, Honolulu, HI 96822, USA;

关键词: marine extract;    antiviral drug;    antiviral activity;    enveloped virus;    secosteroids;   

DOI  :  10.3390/md10030521

来源: mdpi

【 摘 要 】

Marine environments are a rich source of significant bioactive compounds. The Hawaiian archipelago, located in the middle of the Pacific Ocean, hosts diverse microorganisms, including many endemic species. Thirty-eight microbial extracts from Hawaiian coastal waters were evaluated for their antiviral activity against four mammalian viruses including herpes simplex virus type one (HSV-1), vesicular stomatitis virus (VSV), vaccinia virus and poliovirus type one (poliovirus-1) using in vitro cell culture assay. Nine of the 38 microbial crude extracts showed antiviral potencies and three of these nine microbial extracts exhibited significant activity against the enveloped viruses. A secosteroid, 5α(H),17α(H),(20R)-beta-acetoxyergost-8(14)-ene was putatively identified and confirmed to be the active compound in these marine microbial extracts. These results warrant future in-depth tests on the isolation of these active elements in order to explore and validate their antiviral potential as important therapeutic remedies.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.