Enhancement of Antimicrobial Activity of Alginate Films with a Low Amount of Carbon Nanofibers (0.1% w/w)

Applied Sciences

Sofía Gandía-Llop¹  Ángel Serrano-Aroca¹  Miguel Martí¹  Beatriz Salesa¹  Finn Lillelund Aachmann²  Isaías Sanmartín-Santos³ 

[1] Biomaterials and Bioengineering Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain;NOBIPOL, Department of Biotechnology and Food Science, NTNU Norwegian University of Science and Technology, Kjemi 4, 4-125, Gløshaugen, Sem Sælands vei 6, 7491 Trondheim, Norway;Structural and Computational Biochemistry Lab, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Quevedo 2, 46001 Valencia, Spain;

关键词: carbon nanofibers;    calcium alginate;    antiviral activity;    antibacterial activity;    enveloped virus;    DNA virus;   

DOI  :  10.3390/app11052311

来源: DOAJ

【 摘 要 】

The World Health Organization has called for new effective and affordable alternative antimicrobial materials for the prevention and treatment of microbial infections. In this regard, calcium alginate has previously been shown to possess antiviral activity against the enveloped double-stranded DNA herpes simplex virus type 1. However, non-enveloped viruses are more resistant to inactivation than enveloped ones. Thus, the viral inhibition capacity of calcium alginate and the effect of adding a low amount of carbon nanofibers (0.1% w/w) were explored here against a non-enveloped double-stranded DNA virus model for the first time. The results of this study showed that neat calcium alginate films partly inactivated this type of non-enveloped virus and that including that extremely low percentage of carbon nanofibers (CNFs) significantly enhanced its antiviral activity. These calcium alginate/CNFs composite materials also showed antibacterial properties against the Gram-positive Staphylococcus aureus bacterial model and no cytotoxic effects in human keratinocyte HaCaT cells. Since alginate-based materials have also shown antiviral activity against four types of enveloped positive-sense single-stranded RNA viruses similar to SARS-CoV-2 in previous studies, these novel calcium alginate/carbon nanofibers composites are promising as broad-spectrum antimicrobial biomaterials for the current COVID-19 pandemic.

【 授权许可】

Unknown