The Coronavirus E Protein: Assembly and Beyond

Viruses

Travis R. Ruch¹ 

[1] Department of Cell Biology, The Johns Hopkins University School of Medicine, 725 N. Wolfe St., Baltimore, MD 21205, USA;

关键词: envelope protein;    coronavirus assembly;    ion channel;    Golgi complex;    membrane protein topology;   

DOI  :  10.3390/v4030363

来源: mdpi

【 摘 要 】

The coronavirus E protein is a small membrane protein that has an important role in the assembly of virions. Recent studies have indicated that the E protein has functions during infection beyond assembly, including in virus egress and in the host stress response. Additionally, the E protein has ion channel activity, interacts with host proteins, and may have multiple membrane topologies. The goal of this review is to highlight the properties and functions of the E protein, and speculate on how they may be related.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.