The Coronavirus Nucleocapsid Is a Multifunctional Protein

Viruses

Ruth McBride¹  Marjorie van Zyl¹ 

关键词: nucleocapsid protein;    coronavirus assembly;    coronavirus N;    intracellular localization;    protein topology;   

DOI  :  10.3390/v6082991

来源: mdpi

【 摘 要 】

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.