New Methodology for the Synthesis of Thiobarbiturates Mediated by Manganese(III) Acetate

Molecules

Ahlem Bouhlel¹  Christophe Curti¹ 

[1] id="af1-molecules-17-04313">Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Bd Jean Moulin, CS 30064, 13385 Marseille Cedex 05, Fran

关键词: manganese(III) acetate;    barbiturates;    radical;   

DOI  :  10.3390/molecules17044313

来源: mdpi

【 摘 要 】

A three step synthesis of various thiobarbiturate derivatives 17–24 was established. The first step is mediated by Mn(OAc)₃, in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 1–8 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.