Molecules | |
Antibacterial Barbituric Acid Analogues Inspired from Natural 3-Acyltetramic Acids; Synthesis, Tautomerism and Structure and Physicochemical Property-Antibacterial Activity Relationships | |
Yong-Chul Jeong2  Mark G. Moloney1  | |
[1] Chemistry Research Laboratory, Mansfield Rd, University of Oxford, OX1 3TA, UK; E-Mail | |
关键词: barbiturates; antibacterial; synthesis; tautomerism; | |
DOI : 10.3390/molecules20033582 | |
来源: mdpi | |
【 摘 要 】
The synthesis, tautomerism and antibacterial activity of novel barbiturates is reported. In particular, 3-acyl and 3-carboxamidobarbiturates exhibited antibacterial activity, against susceptible and some resistant Gram-positive strains of particular interest is that these systems possess amenable molecular weight, rotatable bonds and number of proton-donors/acceptors for drug design as well as less lipophilic character, with physicochemical properties and ionic states that are similar to current antibiotic agents for oral and injectable use. Unfortunately, the reduction of plasma protein affinity by the barbituric core is not sufficient to achieve activity
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190016126ZK.pdf | 2391KB | download |