Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua

Molecules

Jian-Yu Liu¹  Ying-Li Guan¹  Li-Bo Zou¹  Yi-Xia Gong¹  Hui-Ming Hua¹  Yong-Nan Xu¹  Hui Zhang¹  Zong-Gui Yu¹ 

[1] ¹Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China

关键词: Pulsatilla cernua;    saponin;    neuroprotective effect;    Alzheimer’s disease;    β-amyloid;   

DOI  :  10.3390/molecules17055520

来源: mdpi

【 摘 要 】

Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is reported for the first time from this genus. Some of these compounds showed significant neuroprotective effects against the cytotoxicity induced by β-amyloid_25–35 (Aβ_25–35) on human neuroblastoma SH-SY5Y cells.

【 授权许可】

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This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.