Molecules | |
A New Iridoid Glycoside from the Roots of Dipsacus asper | |
De Ji1  Chunfeng Zhang1  Jingzhi Li1  Haowei Yang1  Jingyang Shen1  | |
[1] State Key Laboratory of Natural Products and Functions, China Pharmaceutical University, Ministry of Education, 24 Tong Jia Xiang, Nanjing 210009, China | |
关键词: Dipsacus asper; iridoid glycoside; loganic acid ethyl ester; neuroprotective effect; Dipsaceae; | |
DOI : 10.3390/molecules17021419 | |
来源: mdpi | |
【 摘 要 】
A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4′,4′′-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ25–35 induced cell death in PC12 cells.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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