A New Iridoid Glycoside from the Roots of Dipsacus asper

Molecules

De Ji¹  Chunfeng Zhang¹  Jingzhi Li¹  Haowei Yang¹  Jingyang Shen¹ 

[1] State Key Laboratory of Natural Products and Functions, China Pharmaceutical University, Ministry of Education, 24 Tong Jia Xiang, Nanjing 210009, China

关键词: Dipsacus asper;    iridoid glycoside;    loganic acid ethyl ester;    neuroprotective effect;    Dipsaceae;   

DOI  :  10.3390/molecules17021419

来源: mdpi

【 摘 要 】

A new iridoid glycoside, named loganic acid ethyl ester (1), together with five known compounds: chlorogenic acid (2), caffeic acid (3), loganin (4), cantleyoside (5) and syringaresinol-4′,4′′-O-bis-β-D-glucoside (6) were isolated from the roots of Dipsacus asper. The structure of compound 1 was elucidated on the basis of detailed spectroscopic analyses. Lignan is isolated from Dipsacaceae species for the first time. Compounds 1, 4 and 5 had moderate neuroprotective effects against the Aβ_25–35 induced cell death in PC12 cells.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.